01 - Pat the tilapia fillets thoroughly dry with paper towels. Season both sides evenly with salt, black pepper, smoked paprika, and garlic powder, pressing the spices gently into the flesh.
02 - Spread the flour in a shallow dish. Lightly dredge each seasoned fillet in the flour, coating both sides evenly, then shake off any excess.
03 - Heat the olive oil and butter together in a large non-stick skillet over medium-high heat until the butter is fully melted and begins to lightly foam.
04 - Carefully place the dredged fillets into the hot skillet, working in batches if needed to avoid crowding. Cook for 3 to 4 minutes per side until the exterior is golden brown and the fish flakes easily when tested with a fork.
05 - Transfer the cooked fillets to a plate lined with fresh paper towels to drain any residual oil.
06 - Sprinkle the chopped parsley over the fillets and serve immediately with lemon wedges alongside.